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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Trends Genet. 2018 Oct 10;34(12):972–990. doi: 10.1016/j.tig.2018.09.006

Figure 3. Model of PUM1/2 repression mechanisms.

Figure 3.

PUM proteins bind the PRE, typically located in the 3´UTR of target mRNAs. Repression of the target mRNA is mediated in at least three ways: (A) The Pum-HDs of PUMs antagonize the translational activity of poly(A) binding protein (PABPC1). (B) PUMs promote translational repression and mRNA decay by recruiting the CCR4-NOT deadenylase complex (CNOT). (C) The N-terminal regions of PUM orthologs confer repression, but the mechanism remains to be determined.