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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Neurobiol Aging. 2018 Sep 15;73:231.e1–231.e6. doi: 10.1016/j.neurobiolaging.2018.09.008

Table 2:

Role of GCH1 in PD - Summary of previous reports

Article Role
in PD
#controls #cases Diagnosis of cases Ethnicity GCH1 findings
Hertz et al., 2006 No 0 87 EOPD Danish No pathogenic GCH1 variants found
Cobb et al., 2009 No 0 53 familial EOPD, 21 with EOPD+dystonia North-American Caucasian No coding changes/CNV
Momma et al., 2009 Yes 96 2 EOPD Chinese 1 rare mutation found in patients
Mencacci et al., 2014 Yes 5935 1318 PD North-American of European descent, Estonians 11 different heterozygous variants at low frequency, 4 of them associated with DRD
Nalls et al., 2014 Yes 95282 13708 PD European ancestry GWAS signal
Newman et al., 2014 No 862 1105 PD/dystonia Australian No association between PD and the analyzed SNPs
Weissbach et al., 2014 Yes 0 15 PD/Parkinsonism/dystonia N/A GCH1 mutation carriers with parkinsonism and idiopathic PD (one had dystonia)
Guella et al., 2015 Yes 290 528 361PD/167 atypical Parkinsonism+DLB+MSA+PSP N/A Rare heterozygous nonsynonymous substitutions found in patients
Lewthwaite et al., 2015 Yes 6 6 2EOPD, 1 Parkinsonism, 3DRD Caucasian 1 novel heterozygous substitution found in a very conserved region
Bandres-Ciga et al., 2016 No 0 134 97LOPD/28EOPD/9FPD South Spanish No mutation carriers for GCH1
Chen et al., 2016 Yes 553 528 PD Taiwanese rs11158026 increased the risk of developing PD
Rengmark et al., 2016 No 230 509 LOPD Norwegian/Swedish No pathogenic GCH1 variants found
Safaralizadeh et al., 2016 Yes 1200 600 PD (excluded EOPD,FPD) Iranian Replicated the association of rs11158026 with PD
Chang et al., 2017 Yes 302042 6476 PD European ancestry GWAS signal
Xu et al., 2017 Yes 1565 1758 PD Chinese 7 rare heterozygous non-synonymous mutations in patients
Yang et al., 2017 No 634 589 sporadic PD (FPD excluded) Han Chinese No association of rs11158026 with PD
Yan et al., 2018 Yes 438 421 170EOPD/251LOPD(FPD excluded) Han Chinese 1 LOPD patient (maybe +dystonia) with rare GCH1 mutation(+1 found earlier)
Zou et al., 2018 No 624 579 sporadic PD (FPD excluded) East Asians No association of rs11158026 with PD

CNV, copy number variation; DLB, dementia with Lewy Bodies; DRD, dopa-responsive dystonia; EOPD, early-onset PD; FPD, familial PD; GWAS, genome wide association study; LOPD, late onset PD; MSA, multiple system atrophy; PSP, progressive supranuclear palsy