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The dual role of p53 in the control of ferroptosis. Ferroptosis is characterized by lipid peroxidation. p53 plays a context-dependent role in the regulation of lipid peroxidation in ferroptosis. On one hand, p53 can enhance ferroptosis through the inhibition of SLC7A11 expression or promotion of SAT1 and GLS2 expression. On the other hand, p53 could suppress ferroptosis through the inhibition of DPP4 activity or induction of CDKN1A/p21 expression.
