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. Author manuscript; available in PMC: 2019 Dec 1.
Published in final edited form as: Hepatology. 2018 Dec;68(6):2197–2211. doi: 10.1002/hep.30097

Figure 7. Fenofibrate reverses ACCi-mediated hypertriglyceridemia in FFD-fed mice.

Figure 7

(A) Male B6 mice were fed a fast food diet (FFD) for 5 months and treated with 1 mg/kg (BID), 5 mg/kg (BID), 10 mg/kg (BID) Compound 1 (ACCi) or vehicle control for 28 days. (B–C) Liver (B) and plasma (C) triglycerides in mice treated as in (A). n = 8–13 per treatment group. (C) Male B6 mice were fed a fast food diet (FFD) for 5 months and treated with vehicle, 10 mg/kg (BID) Compound 1 (ACCi), or 10 mg/kg ACCi (BID) and fenofibrate (0.1% in chow, feno) for 14 days. (D) Plasma triglycerides (pooled samples collected at 2, 6, and 24 h post dose) in mice treated as in (C). Values are expressed as percent of vehicle-treated animals collected at the same time of day after treatment with vehicle, ACCi or ACCi + fenofibrate. (D) mRNA expression of SREBP1c and PLIN2 (a canonical PPARα target) in the livers of mice treated as in (C). Data are presented as mean ± SEM. In panels (B-C), *P ≤ 0.05 compared to vehicle control by one-way ANOVA with Dunnett correction for multiple comparisons. In panels (D-E), *P ≤ 0.05 by unpaired student's t-test. BID: twice daily; QD: once daily.