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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: ASAIO J. 2019 May-Jun;65(4):401–407. doi: 10.1097/MAT.0000000000000822

Figure 3.

Figure 3

Biomarkers of organ injury were significantly lower in pigs that received 8 hours of L-MOD therapy. Panel A) Serum concentration of cardiac Troponin -I was increased at the end of CPB (END CPB) and at 5 hours post CPB (5h). A cardioprotective effect of L-MOD was observed in Group 3 with the average value for this myocardial injury marker being significantly lower at 5 hours post CPB compared to both Group 1 and to Group 2 (p <0.05). Panel B) At 5 hours post CPB, urine levels neutrophil gelatinase associated lipocalin (NGAL), a marker of acute kidney injury, were increased several-fold in multiple animals from Group 1 and Group 2. No pig in Group 3 had a urine NGAL concentration that exceeded the average baseline value and the mean NGAL concentration at 5 hours post CPB was significantly lower for Group 3 (7.57 ± 3.6 ng/ml) compared to the mean of all other pigs (50.71 ± 49.17 ng/ml, p <0.05). Horizontal lines, mean value.