Table 1.
Entry | R1 | R2 | Product | Time (min) | Yielda (%) | Mp (°C) | |
---|---|---|---|---|---|---|---|
Observed | Literature | ||||||
1 | H | H | 4a | 60 | 88 | 134–137 | 135–13764 |
2 | H | 4-Cl | 4b | 60 | 94 | 121–123 | 123–12465 |
3 | H | 4-NO2 | 4c | 60 | 91 | 193–194 | 196–19864 |
4 | H | 4-OH | 4d | 60 | 88 | 199–200 | 196–19865 |
5 | H | 4-Me | 4e | 60 | 83 | 117–120 | 119–12056 |
6 | H | 4-Br | 4f | 60 | 90 | 162–163 | 165–16665 |
7 | H | 4-OMe | 4g | 60 | 83 | 98–100 | 97–9866 |
8 | 4-Cl | H | 4h | 60 | 84 | 180–181 | 175–17856 |
9 | 4-Cl | 4-OMe | 4i | 60 | 88 | 188–189 | 190–19167 |
10 | 4-Me | 4-Cl | 4j | 60 | 89 | 162–164 | 159–16064 |
11 | H | furan-2-carbaldehyde | 4k | 60 | 75 | 110–112 | 112–11568 |
aIsolated yield.