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. 2018 Nov 23;8:17307. doi: 10.1038/s41598-018-35612-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PSA^hi ENZ^R cells are sensitive to STAT3 inhibition by gallielalactone (GPA500). (A) Relative 72 hour cell proliferation assay using WST8 in 16D CRPC, 49 C and 49 F cells treated with indicated concentrations of GPA500 compared to untreated. (B) Protein expression of c-Myc, CyclinD1 and Vinculin and (C) Relative mRNA expression of c-Myc, CyclinD1 and bFGF in 16D^CRPC and PSA^hi ENZ^R cells (49 C and 49 F) treated with 0, 5 or 10 µM GPA500. (D) Cell cycle fraction of 16D^CRPC and PSA^hi ENZ^R cells 49 C and 49 F following GPA500 treatment (48 hour with indicated concentrations). All graphs represent pooled data from 3 independent experiments in triplicates.