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. 2018 Nov 23;8:17307. doi: 10.1038/s41598-018-35612-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of STAT3 reduces AR activity in PSA^hi ENZ^R cells in vivo. (A) Weekly mean tumour volume (Left) and serum prostate-specific antigen (PSA) levels (Right) in mice treated with GPA500 5 mg/kg/day versus vehicle. Treatment was started when tumours reached 200 mm³ and was given intraperitoneally for 5 days on and 2 days off. (B) Protein expression of PSA, CyclinD1 and Vinculin in collected tumors treated with vehicle (control M1, M2 and M3) or GPA500 5 mg/kg (M4, M5 and M6).