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. 2018 Nov 23;8:17312. doi: 10.1038/s41598-018-35531-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Differentially expressed miRNAs as measured in small RNA-seq data of S2 cells and derived EVs. Differential expression analysis was performed using edgeR on three biological replicates of both groups. MiRNAs were retained with a CPM above 1 in at least 3 samples. (A) Volcano plot indicating 31 significantly different miRNAs in S2 cells and EVs (red dots) and (B) the corresponding Venn diagram presenting the amount of miRNAs with increased (24) or decreased (7) abundance in S2 EVs compared to S2 cells. Abbreviations: EV: extracellular vesicle.