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. 2018 Nov 23;8(12):123. doi: 10.1038/s41408-018-0155-7

Table 2.

Logistic regression, 10-year survival vs. 2-year death

Factors differentiating 10-year survival vs. 2-year death
Variable N Survival less than 2 years Survival more than 10 years OR (95% CI) P-value
Univariate
Age at registration > = 65 yr 2374 163/214 (76%) 1271/2160 (59%) 2.24 (1.61, 3.10)  < 0.001
IgA 1878 306/463 (66%) 785/1415 (55%) 1.56 (1.26, 1.95)  < 0.001
IgG 1878 580/1080 (54%) 511/798 (64%) 0.65 (0.54, 0.79)  < 0.001
Female 1918 493/827 (60%) 685/1091 (63%) 0.87 (0.73, 1.05) 0.157
Albumin < 3.5 g/dL 2206 559/808 (69%) 737/1398 (53%) 2.01 (1.68, 2.42)  < 0.001
B2M > = 3.5 mg/L 2208 833/1123 (74%) 488/1085 (45%) 3.51 (2.94, 4.20)  < 0.001
B2M > 5.5 mg/L 2208 501/630 (80%) 820/1578 (52%) 3.59 (2.89, 4.46)  < 0.001
Creatinine > = 2 mg/dL 2320 353/430 (82%) 1042/1890 (55%) 3.73 (2.87, 4.85)  < 0.001
HGB < 10 g/dL 2313 678/908 (75%) 699/1405 (50%) 2.98 (2.48, 3.57)  < 0.001
LDH > Upper Limit Normal 935 196/260 (75%) 354/675 (52%) 2.78 (2.02, 3.82)  < 0.001
Platelet Count < 150 × 10^9/L 2241 364/443 (82%) 969/1798 (54%) 3.94 (3.04, 5.11)  < 0.001
Any clonal abnormality by cytogenetics 507 92/145 (63%) 127/362 (35%) 3.21 (2.15, 4.80)  < 0.001
BMPC > = 30% 1933 800/1226 (65%) 317/707 (45%) 2.31 (1.91, 2.79)  < 0.001
ISS Stage 1 2070 296/761 (39%) 910/1309 (70%) 0.28 (0.23, 0.34)  < 0.001
ISS Stage 2 2105 477/756 (63%) 759/1349 (56%) 1.33 (1.11, 1.60) 0.002
ISS Stage 3 2208 501/630 (80%) 820/1578 (52%) 3.59 (2.89, 4.46)  < 0.001
Multivariate (stratified by country)
Age at registration > = 65 yr 1230 98/144 (68%) 525/1086 (48%) 1.87 (1.26, 2.79) 0.002
IgA 1230 180/298 (60%) 443/932 (48%) 1.53 (1.15, 2.04) 0.004
Albumin < 3.5 g/dL 1230 294/474 (62%) 329/756 (44%) 1.36 (1.04, 1.78) 0.023
B2M > = 3.5 mg/L 1230 376/569 (66%) 247/661 (37%) 1.86 (1.41, 2.45)  < 0.001
Creatinine > = 2 mg/dL 1230 130/174 (75%) 493/1056 (47%) 1.77 (1.18, 2.65) 0.005
HGB < 10 g/dL 1230 288/429 (67%) 335/801 (42%) 1.55 (1.16, 2.06) 0.003
Platelet Count < 150 × 10^9/L 1230 163/218 (75%) 460/1012 (45%) 2.26 (1.59, 3.22)  < 0.001

P-value from Wald chi-square test in logistic regression. NS2–Multivariate results not statistically significant at 0.05 level. Univariate p-values reported regardless of significance. Multivariate model uses stepwise selection with entry level 0.1 and variable remains if meets the 0.05 level. A multivariate p-value greater than 0.05 indicates variable forced into model with significant variables chosen using stepwise selection

OR odds ratio, 95% CI 95% confidence interval