Table 2.
Logistic regression, 10-year survival vs. 2-year death
| Factors differentiating 10-year survival vs. 2-year death | |||||
|---|---|---|---|---|---|
| Variable | N | Survival less than 2 years | Survival more than 10 years | OR (95% CI) | P-value |
| Univariate | |||||
| Age at registration > = 65 yr | 2374 | 163/214 (76%) | 1271/2160 (59%) | 2.24 (1.61, 3.10) | < 0.001 |
| IgA | 1878 | 306/463 (66%) | 785/1415 (55%) | 1.56 (1.26, 1.95) | < 0.001 |
| IgG | 1878 | 580/1080 (54%) | 511/798 (64%) | 0.65 (0.54, 0.79) | < 0.001 |
| Female | 1918 | 493/827 (60%) | 685/1091 (63%) | 0.87 (0.73, 1.05) | 0.157 |
| Albumin < 3.5 g/dL | 2206 | 559/808 (69%) | 737/1398 (53%) | 2.01 (1.68, 2.42) | < 0.001 |
| B2M > = 3.5 mg/L | 2208 | 833/1123 (74%) | 488/1085 (45%) | 3.51 (2.94, 4.20) | < 0.001 |
| B2M > 5.5 mg/L | 2208 | 501/630 (80%) | 820/1578 (52%) | 3.59 (2.89, 4.46) | < 0.001 |
| Creatinine > = 2 mg/dL | 2320 | 353/430 (82%) | 1042/1890 (55%) | 3.73 (2.87, 4.85) | < 0.001 |
| HGB < 10 g/dL | 2313 | 678/908 (75%) | 699/1405 (50%) | 2.98 (2.48, 3.57) | < 0.001 |
| LDH > Upper Limit Normal | 935 | 196/260 (75%) | 354/675 (52%) | 2.78 (2.02, 3.82) | < 0.001 |
| Platelet Count < 150 × 10^9/L | 2241 | 364/443 (82%) | 969/1798 (54%) | 3.94 (3.04, 5.11) | < 0.001 |
| Any clonal abnormality by cytogenetics | 507 | 92/145 (63%) | 127/362 (35%) | 3.21 (2.15, 4.80) | < 0.001 |
| BMPC > = 30% | 1933 | 800/1226 (65%) | 317/707 (45%) | 2.31 (1.91, 2.79) | < 0.001 |
| ISS Stage 1 | 2070 | 296/761 (39%) | 910/1309 (70%) | 0.28 (0.23, 0.34) | < 0.001 |
| ISS Stage 2 | 2105 | 477/756 (63%) | 759/1349 (56%) | 1.33 (1.11, 1.60) | 0.002 |
| ISS Stage 3 | 2208 | 501/630 (80%) | 820/1578 (52%) | 3.59 (2.89, 4.46) | < 0.001 |
| Multivariate (stratified by country) | |||||
| Age at registration > = 65 yr | 1230 | 98/144 (68%) | 525/1086 (48%) | 1.87 (1.26, 2.79) | 0.002 |
| IgA | 1230 | 180/298 (60%) | 443/932 (48%) | 1.53 (1.15, 2.04) | 0.004 |
| Albumin < 3.5 g/dL | 1230 | 294/474 (62%) | 329/756 (44%) | 1.36 (1.04, 1.78) | 0.023 |
| B2M > = 3.5 mg/L | 1230 | 376/569 (66%) | 247/661 (37%) | 1.86 (1.41, 2.45) | < 0.001 |
| Creatinine > = 2 mg/dL | 1230 | 130/174 (75%) | 493/1056 (47%) | 1.77 (1.18, 2.65) | 0.005 |
| HGB < 10 g/dL | 1230 | 288/429 (67%) | 335/801 (42%) | 1.55 (1.16, 2.06) | 0.003 |
| Platelet Count < 150 × 10^9/L | 1230 | 163/218 (75%) | 460/1012 (45%) | 2.26 (1.59, 3.22) | < 0.001 |
P-value from Wald chi-square test in logistic regression. NS2–Multivariate results not statistically significant at 0.05 level. Univariate p-values reported regardless of significance. Multivariate model uses stepwise selection with entry level 0.1 and variable remains if meets the 0.05 level. A multivariate p-value greater than 0.05 indicates variable forced into model with significant variables chosen using stepwise selection
OR odds ratio, 95% CI 95% confidence interval