Table 2.
Application of quality-adjusted survival analysis using duration (QASAD) and quality-adjusted survival analysis using probability (QASAP) on RTOG 85-31.
| Analytic conditions | QASAD |
QASAP |
||||||
|---|---|---|---|---|---|---|---|---|
| QALY values (multiplicative) |
QALY values (minimum) |
QALY values (multiplicative) |
QALY values (minimum) |
|||||
| RT | RT + ADT | RT | RT + ADT | RT | RT + ADT | RT | RT + ADT | |
| Overall QALY value | 4.9 | 5.57 | 4.92 | 5.6 | 4.83 | 4.93 | 4.89 | 5.02 |
| One-way sensitivity analysis | ||||||||
| States | ||||||||
| Remission = 1 | 5.04 | 5.57 | 5.04 | 5.6 | 5.06 | 4.93 | 5.11 | 5.02 |
| BCR = 0.943 | 5.24 | 6.48 | 5.25 | 6.49 | 5.14 | 5.79 | 5.19 | 5.82 |
| BCR = 0.643 | 4.57 | 4.66 | 4.58 | 4.69 | 4.58 | 4.08 | 4.64 | 4.16 |
| Recurrence = 0.51 | 5.23 | 5.74 | 5.24 | 5.77 | 5 | 5.03 | 5.07 | 5.12 |
| Recurrence = 0.33 | 4.58 | 5.41 | 4.59 | 5.44 | 4.66 | 4.84 | 4.72 | 4.93 |
| Toxicity | ||||||||
| RT = 0.942 | 4.93 | 5.59 | 4.94 | 5.6 | 4.85 | 4.96 | 4.92 | 5.02 |
| RT = 0.678 | 4.88 | 5.55 | 4.89 | 5.58 | 4.81 | 4.91 | 4.87 | 5 |
| Grade 2 + GU = 0.775 | — | — | — | — | 4.81 | 4.92 | 4.88 | 5.01 |
| Grade 2 + GU = 0.925 | — | — | — | — | 4.85 | 4.95 | 4.9 | 5.02 |
| Grade 2 + GI = 0.7 | — | — | — | — | 4.82 | 4.92 | 4.88 | 5.01 |
| Grade 2 + GI = 0.9 | — | — | — | — | 4.85 | 4.95 | 4.9 | 5.02 |
| Probabilistic sensitivity analysis (95% CI) | 4.93 (4.12–5.71) | 5.60 (4.30–6.48) | 4.94 (4.14–5.72) | 5.62 (4.33–6.49) | 4.85 (4.16–5.39) | 4.96 (3.73–5.78) | 4.91 (4.24–5.44) | 5.04 (3.79–5.82) |
BCR, biochemical recurrence; CI, confidence interval; GI, gastrointestinal; GU, genitourinary; QALY, quality-adjusted life year; RTOG, Radiation Therapy Oncology Group; RT, radiation therapy; RT + ADT, radiation therapy plus androgen deprivation therapy. “Multiplicative” and “minimum” refer to the method used to calculate the QALY values (see Supplementary data in Online Resource 1).