Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The processes of mRNA N6-methyladenosine modification regulated by m6A modification “writers”, “erasers” and “readers”. The m6A modification methylation and demethylation occur in the nucleus. The m6A-containing RNAs are recognized by the m6A readers, such as HNRNPA2B1, YTHDC1 and HNRNPC, which affect the splicing and export of these mRNAs. In the cytoplasm, the m6A-“imprinting” mRNA is recognized by YTHF1–3 and IGF2BP1–3, which affecting the mRNA stability, translation and decay.
