Fig. 4.

Resveratrol restores hypoxia-depleted ASL Depth. Murine nasal epithelial cultures exhibit similar reduction in ASL with hypoxia as human sinonasal epithelium. Cultures were incubated for 24 h in 1% oxygen and followed by 30 min incubation with resveratrol or DMSO control vehicle and measured by confocal laser scanning microscopy (Panel A represents confocal images, cells – green, ASL - red). Resveratrol treatment significantly mitigated hypoxia-induced reductions in ASL depth (3.13 ± 0.17 μm (DMSO + hypoxia) vs. 5.55 ± 0.74 μm (resveratrol + hypoxia) P < 0.05) (B). (Adapted from ⁸).