Figure 7.
Centrosome Amplification in Breast Cancer Mediates Paracrine Invasion and Is Associated with IL-8 Secretion
(A) Quantification of round invasive and tubular structures in PyMT-derived tumor organoids.
(B) Tumor organoids. Scale bar: 20 μM.
(C) Area and branching of the tumor organoids. Error bars represent mean ± SEM.
(D) PyMT tubular organoids. Scale bar: 100 μM.
(E) Levels of centrosome amplification and breast cancer subtype.
(F) mRNA expression levels of pro-invasive factors.
(G) Quantification of invasive structures.
(H) Schematic representation of how centrosome amplification promotes secretion and paracrine invasion.
Unless specified, for all graphics, error bars represent mean ± SD from three independent experiments. ∗p < 0.05, ∗∗p < 0.01; ns, not significant.