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. 2016 Feb 15;25(7):1308–1321. doi: 10.1016/j.sjbs.2016.02.017

Table 8.

Kinetic models applied for estimation of kinetic parameters and kinetic constants values for butanol production, biomass growth and substrate consumption for scale-up fermentation by 5L bioreactor and flask scale fermentation.

Parameter estimation Fermentation process
Model
Bioreactor scale up Flask scale
Butanol production
 P0 (g/L) 0.001 0.009 P=P0PmaxePttPmax-P0+P0ePtt
 Pmax (g/L) 17.005 13.822
 Pt 0.0754 0.068
 R2 (regression coefficient) 0.999 0.988
 δ (variance) 0.0353 0.412
 MSE 0.0413 0.1601



Biomass
 X0 0.205 0.303 X=X0Xmeμ0tXm-X0+X0eμ0t
 Xm 1.742 1.710
 μ0 0.241 0.189
 R2 (regression coefficient) 0.975 0.981
 δ (variance) 0.0098 0.0039
 MSE 0.0218 0.0156



Glucose consumption
 S0 50.80 50.30 S=S0-1Yp/s(P-P0)+1Yx/s(X-X0)
 YP/S 0.363 0.310
 R2 (regression coefficient) 0.999 0.999
 δ (variance) 0.06826 0.02032
 MSE 0.04563 0.00378

Mean squares error (MSE).