Table 1.

Structure and targets of antibody–drug conjugates (ADCs)

ADC name	Antibody origin	Target	Linker	Payload
Gemtuzumab ozogamicin	Humanized	CD33	4-(4-Acetylphenoxy)butanoic acid	NAC
Brentuximab vedotin	Chimeric	CD30	Valine-citrulline	MMAE
Trastuzumab emtansine	Humanized	HER2	MCC	DM1
Inotuzumab ozogamicin	Humanized	CD22	4-(4-Acetylphenoxy)butanoic acid	NAC

CD20/22/30 B-cell receptor CD20/22/30, DM1 emtansine, HER2 human epidermal growth factor receptor 2, MCC maleimidomethyl cyclohexane-1-carboxylate, MMAE monomethyl aurostatin E, NAC N-acetyl-γ-calicheamicin