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A model for how the Bwc1-Bwc2 complex impacts on C. neoformans biology. In the presence of light, blue wavelengths are absorbed by a flavin molecule, the signal transmitted to alter transcription, and mating inhibited while resistance to UV is increased. In darkness, or when the flavin-binding capabilities of Bwc1 are impaired, transcription still occurs to regulate genes that are required for virulence. Such virulence genes currently remain undiscovered.
