Table 2.
Genetic variants associated with cognitive domains.
| rsID | CHR | BP | A1 | BETA | STAT | p-value | Gene | |
|---|---|---|---|---|---|---|---|---|
| Speed of Processing | rs1149530 | 7 | 16848375 | T | 0.77 | 5.1 | 6.4×10−7 | |
| rs818800 | 7 | 16846521 | G | 0.73 | 4.9 | 1.4×10−6 | ||
| rs11763030 | 7 | 16887616 | A | 0.62 | 4.9 | 1.9×10−6 | ||
| Attention/Vigilance | rs830786 | 8 | 76355875 | T | −1.5 | −5.6 | 4.9×10−8 | HNF4G |
| rs75131442 | 8 | 76831979 | T | −1.8 | −5.3 | 3.3×10−7 | ||
| rs79963003 | 8 | 76874205 | A | −1.6 | −5.2 | 4.0×10−7 | ||
| Working Memory | rs17511050 | 4 | 133842651 | T | −1.4 | −5.3 | 2.8×10−7 | |
| rs148396385 | 2 | 151173721 | G | −1.0 | −5.3 | 2.9×10−7 | ||
| rs17396139 | 4 | 162285366 | C | −0.42 | −5.2 | 4.0×10−7 | ||
| Verbal Memory | rs67017972 | 5 | 53071288 | A | 0.60 | 5.7 | 4.3×10−8 | NDUFS4 |
| rs7164861 | 15 | 89125815 | T | −1.3 | −5.4 | 1.6×10−7 | ||
| rs78096325 | 9 | 20207963 | A | −1.2 | −5.2 | 3.3×10−7 | ||
| Visual Memory | rs776010265 | 9 | 126073408 | G | −0.49 | −5.0 | 1.0×10−6 | |
| rs2900031 | 14 | 48879362 | T | 0.59 | 5.0 | 1.4×10−6 | ||
| rs7156750 | 14 | 48885146 | T | 0.48 | 4.9 | 1.7×10−6 | ||
| Reasoning/Problem Solving | rs74412765 | 14 | 34522904 | T | −1.7 | −5.7 | 3.2×10−8 | LOC102724945 |
| rs76872642 | 7 | 18669403 | A | −3.4 | −5.6 | 5.3×10−8 | HDAC9 | |
| rs114499642 | 13 | 104628385 | G | −2.6 | −5.6 | 6.0×10−8 | ||
| CMINDS Composite Score | rs150466277 | 19 | 50957600 | C | −2.8 | −5.4 | 1.4×10−7 | |
| rs80284955 | 18 | 41042547 | G | −1.1 | −5.3 | 2.5×10−7 | ||
| rs185342442 | 13 | 98503979 | G | −3.1 | −5.2 | 3.9×10−7 |
rsID=SNP ID; CHR=chromosome; BP=base pair position; A1=minor allele; BETA=regression coefficient; STAT=t-statistic; Gene=lists a known gene near SNPs that are significant at about p<5.0×10−8.