Table 3.
Gene set analysis based on GWAS results identified unique (non-shaded) and shared genes (shaded) associated with cognitive domain scores
| Speed of Processing | p-value | Attention/Vigilance | p-value | Working Memory | p-value | Verbal Memory | p-value | Visual Memory | p-value | Reasoning/Problem Solving | p-value | CMINDS Composite Score | p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AGR2 | 0.0002 | ACD | 0.00077 | ACD | 0.00017 | C10orf25 | 0.00095 | ADH1A | 0.00115 | APIP | 0.00044 | ACD | 0.00041 |
| AGR3 | 0.0004 | ABCB1 | 0.00076 | BRF2 | 0.00010 | DTYMK | 0.00057 | AGAP11 | 0.00109 | BAG4 | 0.00068 | ABCA11P | 0.00069 |
| ANGEL1 | 0.0009 | ACTR3 | 0.00092 | C5orf22 | 2.31E-005 | FAM200B | 0.00092 | ALOX12 | 0.00011 | CATSPER2 | 0.00052 | ALOX12 | 0.00032 |
| ANGEL2 | 0.0010 | C16orf86 | 0.00077 | C16orf86 | 0.00017 | GCSAML | 0.00097 | ARL6 | 0.00064 | CHN1 | 0.00048 | C16orf86 | 0.00041 |
| ATF1 | 0.0016 | C19orf48 | 0.00014 | CCDC42B | 0.00029 | GTF2H1 | 0.00011 | C17orf49 | 0.00058 | CKMT1B | 0.00048 | C17orf49 | 0.00078 |
| BTD | 0.0010 | CBWD6 | 0.00074 | CTCF | 0.00033 | HOXD-AS1 | 0.00035 | CAMK2N2 | 0.00064 | CLTA | 0.00082 | BLVRA | 0.00105 |
| CDH1 | 0.0002 | CEBPA | 0.00084 | DDX54 | 0.00045 | HOXD-AS2 | 0.00048 | COL28A1 | 0.00039 | CYP2A13 | 0.00033 | BRINP2 | 0.00061 |
| CDH3 | 0.0002 | CEBPA-AS1 | 0.00065 | E2F2 | 0.00029 | HOXD1 | 0.00080 | DACT2 | 5.89E-005 | CYP2F1 | 0.00058 | ATP6V1B1 | 0.00110 |
| DIO3 | 0.0017 | ENKD1 | 0.00077 | ENKD1 | 0.00017 | HOXD3 | 0.00017 | DDOST | 0.00100 | DDHD2 | 0.00031 | ENKD1 | 0.00041 |
| DIO3OS | 0.0007 | EVPLL | 0.00063 | FAM102A | 0.00048 | HOXD4 | 0.00010 | DNALI1 | 9.88E-005 | FGFR1 | 0.00011 | CCDC116 | 0.00033 |
| FLJ43681 | 0.0017 | FKBP9 | 0.00086 | GPR124 | 0.00016 | HOXD8 | 0.00094 | ECE2 | 0.00061 | FKBP9 | 0.00015 | DCLK3 | 0.00034 |
| HIF1AN | 0.0011 | FOXD4L6 | 0.00075 | GFOD2 | 0.00025 | HSPA13 | 0.00044 | FAM25A | 0.00044 | HIC1 | 0.00065 | GFOD2 | 0.00083 |
| HSPA8 | 0.0016 | HSPA8 | 0.00029 | IQCD | 0.00039 | ING5 | 0.00034 | GLUD1 | 0.00123 | KLRG2 | 0.00069 | EIF4E3 | 0.00093 |
| HYAL1 | 0.0015 | HAX1 | 0.00059 | IRF4 | 0.00048 | LDHA | 0.00039 | GNL2 | 0.00043 | LETM2 | 0.00012 | C9orf92 | 8.59E-005 |
| LINC00687 | 0.0012 | KLK1 | 4.38E-006 | KLK1 | 0.00040 | LDHC | 0.00075 | LOC101927780 | 0.00060 | MEPCE | 0.00057 | FARP2 | 0.00053 |
| LOC101927881 | 0.0014 | KLK15 | 3.01E-006 | KLK15 | 0.00030 | LOC101928869 | 0.00052 | LINC00656 | 0.00061 | MIR132 | 0.00074 | GSTM2P1 | 0.00071 |
| NDUFB8 | 0.0007 | KLK3 | 1.66E-006 | KLK3 | 0.00014 | LOC102800310 | 0.00033 | LOC101928035 | 0.00105 | MIR1343 | 0.00067 | LOC100289361 | 0.00068 |
| LOC442497 | 0.0013 | KLK2 | 3.07E-006 | LOC100506178 | 0.00045 | MATR3 | 0.00025 | LINC00458 | 4.16E-005 | MIR212 | 0.00075 | LINC00458 | 0.00068 |
| LRRC74 | 0.0014 | KLKP1 | 6.88E-006 | LOC401320 | 0.00039 | MIR10B | 0.00017 | LOC100506713 | 0.00011 | MIR6840 | 0.00057 | LOC100506713 | 0.00039 |
| LOC341056 | 0.0012 | LOC341056 | 0.00082 | MIR6762 | 0.00048 | MIR1228 | 0.00093 | LOC101929420 | 4.04E-006 | OR5A1 | 0.00083 | LOC101927750 | 0.00068 |
| MIR4311 | 0.0011 | LARS2-AS1 | 0.00100 | MIR7106 | 0.00039 | MIR4781 | 0.00062 | MIR1470 | 0.00024 | OR5A2 | 0.00036 | MIR130B | 0.00067 |
| MIR6872 | 0.0012 | LINC01210 | 0.00066 | MPZ | 0.00045 | MZB1 | 0.00088 | MIR195 | 0.00071 | OR5AN1 | 0.00069 | MIR195 | 0.00094 |
| MYF6 | 0.0012 | LOC100499194 | 0.00031 | NEUROD6 | 3.34E-005 | NDUFA4L2 | 0.00044 | MIR497 | 0.00071 | PILRB | 0.00050 | MIR497 | 0.00094 |
| MCEMP1 | 0.0012 | LAMA4 | 0.00056 | R3HCC1L | 0.00035 | NOMO3 | 0.00049 | MIR497HG | 0.00071 | PMS2P1 | 0.00035 | MIR497HG | 0.00094 |
| NHEG1 | 0.0004 | LOC440896 | 0.00075 | PPM1B | 0.00011 | NXPH4 | 0.00073 | PPM1B | 0.00024 | PPAPDC1B | 0.00029 | PPM1B | 0.00012 |
| NPBWR2 | 0.0010 | MGC45922 | 8.75E-006 | PTN | 0.00013 | OR10S1 | 0.00030 | PAQR9 | 0.00073 | PPP1R35 | 0.00081 | PAQR9 | 0.00074 |
| OPRL1 | 0.0017 | PARD6A | 0.00077 | PARD6A | 0.00017 | OR2G2 | 0.00030 | MN1 | 9.86E-005 | PVRIG2P | 0.00069 | PARD6A | 0.00041 |
| PCP2 | 0.0017 | OR5AR1 | 0.00052 | RASAL1 | 0.00026 | OR4D5 | 0.00014 | PPIL2 | 0.00013 | RP9P | 0.00028 | PPIL2 | 0.00018 |
| RETN | 0.0010 | OR5M11 | 0.00080 | RNU6-83P | 0.00018 | OR6T1 | 9.57E-005 | PINK1-AS | 0.00114 | RNU6-83P | 0.00012 | MIR301B | 0.00067 |
| RPS6KC1 | 0.0006 | OR5M3 | 0.00061 | RLTPR | 0.00044 | OR8D4 | 0.00026 | MIR5581 | 0.00116 | SERF2 | 0.00078 | RLTPR | 0.00069 |
| SEC31B | 0.0009 | RUNDC3B | 0.00057 | RUNDC3B | 0.00011 | PAIP2 | 0.00095 | PROK2 | 0.00047 | SLC4A4 | 0.00063 | RNASE10 | 0.00071 |
| SEMA3B-AS1 | 0.0015 | OR5M9 | 0.00082 | SDHC | 0.00038 | RPF2 | 0.00021 | RNASEK | 0.00046 | SMG6 | 0.00018 | RNASEK | 0.00066 |
| SLC35D3 | 0.0011 | OR9G1 | 0.00084 | SLC25A40 | 0.00033 | SHMT2 | 0.00062 | RNASEK-C17orf49 | 0.00056 | SPDYE3 | 0.00021 | RNASEK-C17orf49 | 0.00074 |
| STXBP2 | 0.0014 | OR9G9 | 0.00084 | SPRR2B | 0.00047 | SLC23A1 | 0.00077 | SNIP1 | 0.00023 | SRSF10 | 0.00030 | SDF2L1 | 0.00038 |
| TFDP2 | 0.0007 | MIR6778 | 0.00097 | SPRR2E | 0.00036 | SNHG4 | 0.00032 | TFAMP1 | 0.00105 | STAG3L5P | 0.00043 | STK25 | 0.00089 |
| TMEM225 | 0.0015 | PGM5P2 | 0.00075 | SPRR2F | 0.00032 | TMEM225 | 0.00055 | TFAP2B | 0.00071 | STAG3L5P-PVRIG2P-PILRB | 0.00040 | TMEM225 | 0.00044 |
| WNT8B | 0.0011 | OR5M8 | 0.00035 | THAP11 | 0.00049 | SPRN | 0.00088 | UBE2L3 | 0.00087 | STRC | 0.00072 | UBE2L3 | 0.00099 |
| TUSC2 | 0.0016 | SNORD88C | 0.00030 | TPCN1 | 0.00048 | STAC3 | 0.00036 | YPEL1 | 0.00033 | TBX21 | 0.00090 | YPEL1 | 0.00033 |
| TSNAXIP1 | 0.0012 | SOX14 | 0.00086 | TSNAXIP1 | 0.00045 | SNORA74A | 0.00036 | WIZ | 0.00039 | WHSC1L1 | 0.00011 | YDJC | 0.00058 |
| ZNF596 | 0.0017 | TOP3A | 0.00084 | ZNF596 | 0.00032 | TMEM59 | 0.00082 | ZNF121 | 0.00105 | ZCWPW1 | 0.00069 | VAX2 | 0.00012 |
The shaded genes are associated with two or more cognitive domains presented on the same row.