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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: J Vasc Surg. 2018 Jul 29;68(6 Suppl):188S–200S.e4. doi: 10.1016/j.jvs.2018.05.206

Fig 4.

Fig 4.

Perivascular delivery of resolvin D1 (RvD1) attenuates neointimal hyperplasia within rabbit vein grafts. Treatment groups consisted of no treatment (bypass only, n = 7) and perivascular application of vehicle (Veh) gels (n = 7), RvD1 gels (n = 7), vehicle wraps (n = 9). A total of 1 μg of RvD1 was delivered for each group (gel or wrap). A-E, Vein grafts were harvested at 28 days after injury, and elastin staining was performed to facilitate morphometric analysis. F-J, Further characterization of the neointima was performed by staining for α-smooth muscle actin (green), followed by nuclear counterstaining with 4’,6-diamidino-2-phenylindole (DAPI; blue). The cellular composition of the neointima appeared similar for all groups. K and L, Quantification of the neointimal thickness, medial thickness, and total vessel thickness was performed. ANOVA, Analysis of variance.