Perivascular delivery of resolvin D1 (RvD1) after vein bypass reduces collagen deposition and fibrosis. A-E, Vein grafts were harvested at 28 days after implantation, and trichrome staining was performed to assess collagen (fibrosis) response. F, Quantification of the collagen staining (blue) was performed using ImageJ. Vein grafts demonstrate positive (outward) remodeling within the first few weeks of implantation. G, This positive remodeling was not compromised by perivascular delivery of RvD1 or vehicle (Veh). ANOVA, Analysis of variance; AU, arbitrary units.