Figure 1. PMAT deficiency mildly affects anxiety-like behaviors.

Anxiety-related behaviors were assessed in the elevated plus maze by measuring A) time spent in the open arms; B) latency to first enter an open arm; C) time spent in the closed arms; and D) total distance traveled in the elevated plus maze during the 5 min test. For B, a latency of 300 s indicates that the mouse did not enter an open arm for the duration of the test. Significant main effects of genotype (p<0.01) were detected for B) latency to first enter an open arm and D) total distance travelled, but post-hoc comparisons did not indicate significant differences compared to wildtype mice. Wildtype mice are indicated as black bars or squares, heterozygous mice as grey bars or diamonds, and knockout mice as white bars or circles. Individual data points are indicated by black squares (wildtypes; female N=11, male N=11), grey diamonds (heterozygotes; female N=9, male N=18), or white circles (knockouts; female N=19, male N=18), and bars indicate the mean + S.E.M.