Table 2.
Effect of the aqueous alkaloid-free extract of C. roseus and its fractions in normal mice.
| Treatment | Dose | Blood glucose reduction (%) | ||
|---|---|---|---|---|
| 2 h | 4 h | 6 h | ||
| Saline solution | 4 mL/kg | 5.8 ± 2.55 | 6.6 ± 1.25 | -5.7 ± 1.49 |
| Glibenclamide | 10 mg/kg | 14.9 ± 2.11∗ | 32.6 ± 0.57∗ | 1.7 ± 2.06∗ |
| Aqueous alkaloid-free extract | 125 mg/kg | 0.8 ± 1.18 | 13.0 ± 1.51∗ | 23.5 ± 1.60∗ |
| 250 mg/kg | 17.9 ± 3.85∗ | 35.3 ± 2.65∗ | 25.0 ± 8.29∗ | |
| 500 mg/kg | 3.7 ± 4.04 | 46.0 ± 1.6∗ | 53.2 ± 1.5∗ | |
| Aqueous fraction | 250 mg/kg | -26.3 ± 7.83 | 25.6 ± 6.15∗ | 22.3 ± 5.58∗ |
| Organic fraction | 250 mg/kg | -29.2 ± 5.53 | 1.3 ± 5.68 | 31.6 ± 5.64∗ |
| Precipitate | 250 mg/kg | -33.5 ± 6.2 | 7.2 ± 3.35 | 48.1 ± 1.55∗ |
Values are the mean percentage of blood glucose reduction (±S.E.M.). ∗ indicates significant differences compared with fasting glycemia (p < 0.05), n=5.