Table 3.
Blood glucose reduction (%) in diabetic mice due to the administration of the aqueous alkaloid-free extract and its fractions obtained from Catharanthus roseus.
| Treatment | Dose | Blood glucose reduction (%) | ||
|---|---|---|---|---|
| 2 h | 4 h | 6 h | ||
| Saline solution | 4 mL/kg | 12.7 ± 7.64 | 15.0 ± 6.42 | 12.5 ± 6.61 |
| Glibenclamide | 10 mg/kg | 24.0 ± 4.68∗ | 37.0 ± 3.61∗ | 43.5 ± 5.98∗ |
| Aqueous alkaloid-free extract | 250 mg/kg | 26.5 ± 7.61∗ | 28.2 ± 7.94∗ | 40.6 ± 6.2∗ |
| Aqueous fraction | 250 mg/kg | 1.2 ± 6.27 | 49.2 ± 7.26∗ | 51.2 ± 19.3∗ |
| Organic fraction | 250 mg/kg | -22.2 ± 4.19 | -0.09 ± 6.32 | 2.9 ± 9.35 |
| Precipitate | 250 mg/kg | 2.6 ± 9.35 | 35.2 ± 4.48∗ | 64.5 ± 1.71∗ |
Values are the mean percentage of blood glucose reduction (±S.E.M.). ∗ indicates significant differences compared with fasting glycemia (p < 0.05), n=5.