Fig. 5.

P2Y₁ receptor does not mediate the current evoked by 2-meSATP. Cardiac ventricular myocytes were prepared from WT hearts, and the effect of MRS-2500 (1 μM) on 2-meSATP-evoked current was measured by voltage clamp in the whole cell configuration. 2-meSATP was present at 3 μM. The ramp voltage clamp was from −100 to +50 mV, as described in methods. The 2-meSATP-evoked current was similar whether or not MRS-2500 was present. Data were shown as current density in pA/pF and were means ± SE of 4 myocytes from 4 mice.