Figure 19.

(a) Molecular structures of the iodo (31) and chloro (32) substituted bis(N-butylindole) squaraine dyes investigated by Zhang et al. and Duan et al., respectively, for PAI (141, 143); (b) PAI of MCF-7 xenografted tumor bearing mice without (I,III, V) and with (II, IV, VI) administration of 31:liposome. (I) and (II) are representative photos of the tumor bearing mice; (III) and (IV) show one transverse slice in the 3D PA image; (V) and (VI) show aligned images from the different transverse section. Reproduced with permission from ref. 141. Copyright 2014 American Chemical Society.