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. Author manuscript; available in PMC: 2019 Nov 13.
Published in final edited form as: Circulation. 2018 Nov 13;138(20):2227–2242. doi: 10.1161/CIRCULATIONAHA.118.035202

Figure 3. Constitutive activation of NLRP3 in cardiomyocytes (CMs) predisposes mice to atrial arrhythmias.

Figure 3

(A–B) Representative WBs and quantification of NLRP3, ASC, and Caspase-1 in atrial tissue of CM-KI and Ctl mice. (C) Representative telemetry ECG recording demonstrated sinus rhythm in Ctl mice and premature atrial contractions (PACs, indicated by arrows) in CM-KI mice. (D) Box plot summarizing the average events of PACs with whiskers indicating the minimum and maximum values in Ctl and CM-KI mice. (E) Representative simultaneous recordings of surface ECG (lead 1) and intracardiac electrograms in CM-KI and Ctl mice following programmed intracardiac stimulation (indicated by arrows). (F) Incidence of pacing-induced AF in Ctl mice (combining WT and Myh6Cre) and CM-KI mice. (G) Representative WBs and quantification of CD68 (macrophage marker) and IL-1β in atrial tissue of CM-KI and Ctl mice. *P<0.05.