Fig. 5.
Bach1 deficiency ameliorated DSS-induced colitis. (A) HO-1 protein expression in the colonic mucosa of Bach1-deficient mice was determined by western blotting. Results are representative of 3 separate experiments. (B) The degree of body weight loss during DSS treatment. Each value indicates the mean ± SE for 6 mice. *p<0.05 compared with wild type mice receiving vehicle, #p<0.05 compared with wild type mice receiving 2% DSS solution. (C) Disease activity index (DAI) on day 7 of DSS treatment. The effect of ZnPP on DAI during the development of DSS-induced colitis in Bach1-deficient mice was also evaluated. Each value indicates the mean ± SE for 5 mice. *p<0.05 compared with wild type mice receiving 2% DSS solution, #p<0.05 compared with Bach1-deficient mice receiving 2% DSS solution.