FIGURE 2.

Myelin remodelling can occur in vivo. (A) Ablation of single sheaths on a fully myelinated axon can induce the rapid growth of neighbouring sheaths to cover the gap. This gap can either be covered entirely by the neighbouring sheaths, or the original myelination profile can be restored by the addition of a new sheath. (B) Ablation of a sheath on a sparsely myelinated axon is followed by formation of a new myelin sheath of identical size and location to the ablated predecessor sheath. Summary of data from Auer et al. (2018).