FIGURE 1.

Hepatitis B virus (HBV) genome, proteins and particle types. (A) Schematic presentation of infectious HB virions (HBV), non-infectious empty envelope particles (SVP) and naked nucleocapids (NC). (B) (Left) HBV genome organization with the two black lines representing the double-stranded covalently closed circular DNA. The four overlapping open reading frames encoding the HBV envelope (Env) proteins (green), the multifunctional viral polymerase (red), the secretory precore and capsid-forming core proteins (orange), and the regulatory X protein (dark blue) are shown. (Right) Domain structures of the viral proteins. Numbers below the rectangles indicate amino acid positions as referred to HBV, genotype D. Of note, the depicted proteins are not drawn to scale.