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. 2018 Nov 19;9:1316. doi: 10.3389/fphar.2018.01316

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Copyright © 2018 Zhou, Hu, Huang, Sang, Song, Wang, Wen, Jiang and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Monte-Carlo simulations of BIS score changing over time during and after a 0.4 mg kg⁻¹ min⁻¹ (infusion within 1 min) initial loading dose of HR7056 followed by 1.0, 1.5, 3.0, and 6.0 mg kg⁻¹ h⁻¹ (infusion for 2 h) maintenance doses, respectively.