Table 1.
Summary of final population pharmacokinetic model of HR7056.
| Parameter | Typical value (RSE%) | 95% CI | IIV% (RSE%) |
|---|---|---|---|
| Central (arterial) volume (L) | 2.11 (4.0) | (1.94–2.27) | 14.0(5.6) |
| Elimination clearance (L min−1) | 1.49 (1.9) | (1.44–1.55) | 11.5 (2.3) |
| Peripheral volume V2 (L) | 10.5 (3.9) | (9.73–11.3) | 12.2 (5.2) |
| Inter-compartmental clearance Cl2 (L min−1) | 0.96 (3.7) | (0.89–1.03) | 13.3 (4.5) |
| Peripheral volume V3 (L) | 22.7 (4.1) | (20.9–24.6) | 25.3 (5.8) |
| Inter-compartmental clearance Cl3 (L min−1) | 0.27 (4.0) | (0.250–0.295) | 18.7 (7.8) |
| σ | 0.138 (2.9) | (0.130–0.145) | – |
–, Not applicable; 95% CI, 95% confidence interval; IIV, Inter-individual variability; RSE%, Percentage relative standard error; σ, Residual variability.