Figure 3.

RaPS Time Frame for the last 14 cases. (Note, the first 10 cases were used for proof of principle and establishment of the workflow). (A) The 5 calendar days time frame was achieved as indicated on the left panel. *To provide a comparison with the time frames published by previous studies,^13–16 we have calculated the median time frame of the last 14 cases from the time library preparation was initialised. Note that the timeframe to ascertain patients was variable and depended on a number of factors such as availability of parents for consenting. (B) Histogram of time frame of genomic sequencing calculated from library preparation to return of clinical findings. Weekends, holidays and delays due to reagents failure or unavailability of sequencers are not excluded from the time frame to reflect real-life working conditions. (C) Table shows the quartile distribution of time frame (calculated from library preparation to return of clinical findings).