Table 1.

Baseline levels of and follow-up changes in serum cytokine concentrations by incident dementia status.

	No incident dementia (N = 473)	Incident dementia (N = 45)	P-value*
BASELINE VALUES
Tumor necrosis factor-α	40.3 (32.5–48.5)	40.7 (31.7–50.4)	0.921
Interleukin-1α	12.1 (11.1–12.9)	11.9 (11.2–14.1)	0.505
Interleukin-1β	9.5 (8.9–10.5)	9.3 (8.8–10.5)	0.981
Interleukin-6	20.0 (18.0–22.3)	21.0 (17.7–25.0)	0.146
Interleukin-8	40.4 (37.3–43.5)	43.0 (40.5–50.3)	<0.001
FOLLOW-UP VALUES
Tumor necrosis factor-α	42.1 (36.5–47.7)	42.1 (37.1–47.1)	0.469
Interleukin-1α	13.2 (12.2–14.2)	13.9 (13.2–14.6)	0.001
Interleukin-1β	10.1 (9.5–11.1)	11.2 (10.0–12.6)	<0.001
Interleukin-6	22.1 (19.5–24.7)	24.6 (22.6–28.1)	<0.001
Interleukin-8	41.1 (38.4–44.6)	45.0 (38.5–53.5)	0.002
CHANGED VALUES
Tumor necrosis factor-α	+1.2 (1.0–1.4)	+4.5 (−0.3–6.0)	0.002
Interleukin-1α	+0.3 (0.3–1.9)	+1.8 (1.1–2.0)	0.001
Interleukin-1β	+0.6 (0.6–0.7)	+2.2 (0.0–2.6)	<0.001
Interleukin-6	+0.6 (0.6–3.3)	+4.8 (0.8–6.0)	0.005
Interleukin-8	+0.3 (0.0–0.6)	+3.6 (−3.9–7.6)	0.100

^*Mann Whitney test, Bold character denotes statistical significance after Bonferroni correction.

Data are median (IQR).