Table 2.
Associations of incident dementia with (binary) higher baseline cytokine levels and (binary) more pronounced increase in levels over follow-up.
| Unadjusted | Adjusteda | |
|---|---|---|
| BASELINE HIGHER LEVELS | ||
| Tumor necrosis factor-α | 1.05 (0.57–1.93) | 0.83 (0.43–1.60) |
| Interleukin-1α | 0.97 (0.47–1.59) | 1.29 (0.65–2.56) |
| Interleukin-1β | 0.78 (0.42–1.45) | 1.09 (0.56–2.14) |
| Interleukin-6 | 1.16 (0.63–2.14) | 1.22 (0.63–2.36) |
| Interleukin-8 | 2.67 (1.37–5.21)† | 2.56 (1.25–5.23)* |
| MORE PRONOUNCED INCREASE IN LEVELS | ||
| Tumor necrosis factor-α | 7.83 (3.92–15.63)‡ | 8.44 (4.02–17.70)‡ |
| Interleukin-1α | 7.26 (3.31–15.95)‡ | 8.20 (3.58–18.82)‡ |
| Interleukin-1β | 7.16 (3.64–14.09)‡ | 7.19 (3.47–14.94)‡ |
| Interleukin-6 | 5.23 (2.63–10.40)‡ | 5.01 (2.43–10.32)‡ |
| Interleukin-8 | 3.80 (2.02–7.16)‡ | 3.73 (1.90–7.32)‡ |
a
Adjusted for age, education, scores on Mini-Mental State Examination and World Health Organization Disability Assessment Scale II, APOE and physical activity.
*
p-value < 0.05;
†
p-value < 0.01;
‡
p-value < 0.001.
Bold character denotes statistical significance after Bonferroni correction.
Data are displayed as odds ratios (95% confidence intervals).