Table 1.

Summary of preclinical pulmonary findings for I-Quit-Ordinary-Smoking (IQOS) compared with sham and 3R4F research cigarette groups

Parameter	Sham (n=10)	IQOS (n=8–10)	3R4F (n=9)
Lung weight (normalised to body weight)	35.8 (1.4)	40.3 (1.0)*	50.6 (1.4)*†
BAL cell count‡ (×105/lung)	22.9 (3.4)	42.5 (7.1)*	116.4 (13.4)*†
BAL inflammatory markers MIP-1β, MCP-3, MPO, PAI-1		↑*	↑*†
Respiratory epithelial hyperplasia and metaplasia		↑*	↑*†

Unless otherwise specified, results signify those from male rats at the highest nicotine exposure levels for each group.

*Significantly increased compared with sham.

†Significantly increased compared with IQOS.

‡Female rats at targeted nicotine 23 µg/L.

BAL, bronchoalveolar lavage; MCP, monocyte chemoattractant protein; MIP, macrophage inflammatory protein; MPO, myeloperoxidase; PAI, plasminogen activator inhibitor.