Figure 8.

The alteration frequencies of hub genes across four different cancer studies.

Notes: (A) A histogram of the alteration frequencies of hub genes across four lung cancer datasets (Pan-Lung Cancer-TCGA, Nat Genet 2016; Lung Adenocarcinoma-TCGA, Provisional; Lung Squamous Cell Carcinoma-TCGA, Provisional; Small Cell Lung Cancer, U Cologne, Nature 2015). (B) Mutation diagram of CENPF in different cancer types across protein domains in lung cancer across protein domains. (C) Mutation diagram of CENPU mutations in lung cancer across protein domains. Downloaded from cBioPortal for Cancer Genomics (http://cbioportal.org).²⁰,⁶⁰

Abbreviations: CENPF, Centromere Protein; CENPU, Centromere Protein U; TCGA, The Cancer Genome Atlas.