Table 1.
Functional and pathway enrichment analysis of upregulated and downregulated genes in lung cancer
| Category | Term | Count | P-value |
|---|---|---|---|
| Upregulated | |||
| GOTERM_BP_DIRECT | GO:0007067–mitotic nuclear division | 22 | 1.51×10−22 |
| GOTERM_BP_DIRECT | GO:0051301–cell division | 21 | 4.40×10−18 |
| GOTERM_BP_DIRECT | GO:0007059–chromosome segregation | 9 | 2.88×10−10 |
| GOTERM_BP_DIRECT | GO:0007062–sister chromatid cohesion | 10 | 3.14×10−10 |
| GOTERM_BP_DIRECT | GO:0006260–DNA replication | 10 | 1.19×10−08 |
| GOTERM_CC_DIRECT | GO:0000775–chromosome, centromeric region | 10 | 6.32×10−13 |
| GOTERM_CC_DIRECT | GO:0030496–midbody | 12 | 1.58×10−12 |
| GOTERM_CC_DIRECT | GO:0000777–condensed chromosome kinetochore | 9 | 1.14×10−09 |
| GOTERM_CC_DIRECT | GO:0005654–nucleoplasm | 32 | 2.78×10−09 |
| GOTERM_CC_DIRECT | GO:0005876–spindle microtubule | 7 | 1.36×10−08 |
| GOTERM_MF_DIRECT | GO:0005524–ATP binding | 21 | 7.75×10−07 |
| GOTERM_MF_DIRECT | GO:0005515–protein binding | 53 | 1.38×10−05 |
| GOTERM_MF_DIRECT | GO:0003777–microtubule motor activity | 6 | 1.62×10−05 |
| GOTERM_MF_DIRECT | GO:0004672–protein kinase activity | 9 | 8.45×10−05 |
| GOTERM_MF_DIRECT | GO:0004674–protein serine/threonine kinase activity | 9 | 1.17×10−04 |
| KEGG_PATHWAY | hsa04110:cell cycle | 8 | 4.38×10−07 |
| KEGG_PATHWAY | hsa04115:p53 signaling pathway | 5 | 1.39×10−04 |
| KEGG_PATHWAY | hsa04512:ECM–receptor interaction | 3 | 4.79×10−02 |
| Downregulated | |||
| GOTERM_BP_DIRECT | GO:0007155–cell adhesion | 11 | 1.17×10−04 |
| GOTERM_BP_DIRECT | GO:0006954–inflammatory response | 8 | 3.29×10−03 |
| GOTERM_BP_DIRECT | GO:0006955–immune response | 8 | 0.006 |
| GOTERM_BP_DIRECT | GO:0016525–negative regulation of angiogenesis | 3 | 0.040 |
| GOTERM_BP_DIRECT | GO:0050727–regulation of inflammatory response | 3 | 0.041 |
| GOTERM_CC_DIRECT | GO:0005576–extracellular region | 22 | 4.82×10−05 |
| GOTERM_CC_DIRECT | GO:0005578–proteinaceous extracellular matrix | 9 | 6.82×10−05 |
| GOTERM_CC_DIRECT | GO:0005887–integral component of plasma membrane | 19 | 2.53×10−04 |
| GOTERM_CC_DIRECT | GO:0045121–membrane raft | 7 | 6.53×10−04 |
| GOTERM_CC_DIRECT | GO:0005615–extracellular space | 17 | 1.22×10−03 |
| GOTERM_MF_DIRECT | GO:0008201–heparin binding | 6 | 9.21×10−04 |
| GOTERM_MF_DIRECT | GO:0050660–flavin adenine dinucleotide binding | 4 | 3.35×10−03 |
| GOTERM_MF_DIRECT | GO:0005178–integrin binding | 4 | 1.31×10−02 |
| GOTERM_MF_DIRECT | GO:0030246–carbohydrate binding | 5 | 1.35×10−02 |
| GOTERM_MF_DIRECT | GO:0044325–ion channel binding | 4 | 1.60×10−02 |
| KEGG_PATHWAY | hsa03320:PPAR signaling pathway | 4 | 7.14×10−03 |
| KEGG_PATHWAY | hsa00350:tyrosine metabolism | 3 | 1.81×10−02 |
Notes: If there were more than five terms enriched in this category, top five terms were selected according to P-value. Count: the number of enriched genes in each term.
Abbreviations: BP, biological process; CC, cellular component; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; MF, molecular function.