Table 2.
Treatment of patients with small cell lung cancer based on the 8th TNM classification (n=277)
| 8th TNM classification | Stage I | Stage II | Stage III | Stage IV | ||
|---|---|---|---|---|---|---|
| M1a | M1b | M1c | ||||
| Number of patients | 11 | 13 | 77 | 38 | 32 | 106 |
| Response to first chemotherapy, n (%) | ||||||
| Complete response | 5 (45) | 4 (30) | 22 (29) | 0 (0) | 0 (0) | 0 (0) |
| Partial response | 2 (18) | 7 (54) | 47 (61) | 24 (63) | 24 (75) | 14 (13) |
| Stable disease | 0 (0) | 0 (0) | 4 (5) | 6 (16) | 4 (13) | 64 (60) |
| Progressive disease | 0 (0) | 1 (8) | 2 (3) | 4 (11) | 2 (6) | 17 (16) |
| Not evaluable | 4 (37) | 1 (8) | 2 (3) | 4(11) | 2(6) | 11(11) |
| Regimen of first chemotherapy, n | ||||||
| OPE + adjuvant chemotherapy | 5 | 1 | 0 | 0 | 0 | 0 |
| Concurrent CRT | 3 | 5 | 32 | 0 | 0 | 0 |
| Sequential CRT | 0 | 1 | 4 | 0 | 0 | 0 |
| CDDP-based doublet | 1 | 0 | 4 | 8 | 4 | 26 |
| CBDCA-based doublet | 2 | 5 | 28 | 16 | 13 | 25 |
| AMR + CPT-11 | 0 | 0 | 2 | 3 | 3 | 6 |
| AMR | 0 | 1 | 7 | 11 | 12 | 49 |
| Number of chemotherapy sessions, n | ||||||
| 1 | 6 | 11 | 34 | 15 | 7 | 54 |
| 2 | 3 | 0 | 23 | 12 | 12 | 35 |
| 3 | 1 | 0 | 15 | 8 | 7 | 10 |
| 4 | 1 | 2 | 3 | 3 | 3 | 4 |
| ≥5 | 0 | 0 | 2 | 0 | 3 | 3 |
| Thoracic radiotherapy, n | ||||||
| No | 8 | 9 | 32 | 32 | 27 | 99 |
| Radical | 3 | 4 | 39 | 0 | 0 | 0 |
| Palliative | 0 | 0 | 6 | 6 | 5 | 7 |
| Cranial radiotherapy, n | ||||||
| None | 10 | 11 | 53 | 30 | 23 | 87 |
| Palliative | 0 | 2 | 12 | 7 | 9 | 19 |
| Prophylactic | 1 | 0 | 12 | 1 | 0 | 0 |
Abbreviations: AMR, amrubicin; CBDCA, carboplatin; CDDP, cisplatin; CPT-11, irinotecan; CRT, chemoradiotherapy; OPE, operation.