Table 3.

Overall survival analyses of the patients with extensive disease small cell lung cancer (n=186)

	Univariate			Multivariate
	HR	95% CI	P-value	HR	95% CI	P-value
Age, ≥75 vs <75 years	1.41	0.98–2.02	0.064
Sex, female vs male	1.19	0.77–1.82	0.44
Smoking status, former/current vs never	1.47	0.55–3.97	0.45
ECOG performance status, 2–4 vs 0–1	1.60	1.15–2.23	0.006	1.28	0.90–1.82	0.17
Brain metastasis, yes vs no	0.98	0.61–1.59	0.94
Albumin, low vs normal	1.84	1.32–2.55	<0.001	1.40	0.99–1.99	0.060
LDH, high vs normal	2.00	1.37–2.89	<0.001	1.73	1.18–2.54	0.005
Sodium, low vs normal	1.41	0.95–2.09	0.090
Platinum-based chemotherapy, yes vs no	0.73	0.53–1.01	0.058
M descriptors, M0/1a/1b vs M1c	2.21	1.58–3.09	<0.001	1.95	1.38–2.77	<0.001

Abbreviations: ECOG, Eastern Cooperative Oncology Group; LDH, lactate dehydrogenase.