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Chemical Structures of Compounds 1 and 2a-m and Their Inhibitory Activities against FP-2.
| Compd | C2 configuration | R1 | R2 | Inhibition rate at 10 μM (%) | IC50 (μM) |
|---|---|---|---|---|---|
| 1 | R |  |
 |
29.4 | 29.7 |
| 2a | S | |
|
14.3 | - |
| 2b | R |  |
|
25.7 | 39.4 |
| 2c | R | |
|
13.0 | - |
| 2d | R | |
 |
11.8 | - |
| 2e | R | |
 |
3.1 | - |
| 2f | R | |
 |
13.6 | - |
| 2g | R | |
 |
3.1 | - |
| 2h | R | |
 |
- | - |
| 2i | R | |
 |
2.2 | - |
| 2j | R | |
 |
6.6 | - |
| 2k | R | |
 |
49.5 | 10.0 |
| 2l | R | |
 |
32.9 | 13.3 |
