Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 19;5:97. doi: 10.3389/fmolb.2018.00097

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Sherman, Jovanovic, Stolnik, Baronian, Downard and Rawson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The transferrin bound cycle of iron uptake. Ferric iron binds to transferrin to form holo-transferrin (Tf). This di-ferric complex then binds to the transferrin receptor 1 (TfR1). Upon binding to the TfR1, the whole complex is internalized via receptor-mediated endocytosis. An ATP driven H⁺ pump drives a pH reduction within the endosome, which causes dissociation of ferric iron from transferrin. The unbound ferric iron is reduced via a transmembrane ferri-reductase to form ferrous iron. The ferrous iron is then transported into the cytoplasm by the DMT1 transporter. The receptor and transferrin protein are then recycled to the surface, ready for the cycle to repeat (not shown). Adapted from Lawen and Lane (2013).