Table 1. Inhibition of Aβ_1–42 aggregation and oxygen radical absorbance capacity (ORAC, Trolox equivalents) of boron-containing compounds 17a–l, 19a and b, resveratrol, curcumin, ferulic acid and (E)-1,3-dimethoxy-5-(4-methoxystyryl)benzene.

Compd.	R1	R2	R3	R4	R5	Inhibition of Aβ1–42 aggregation a (%)	Aβ1–42 IC50 d (μM)	ORAC b
17a	H	H	OH	H	OH	67.3 ± 4.6	12.6 ± 2.8	3.00 ± 0.15
17b	N(CH3)2	H	OH	H	OH	32.4 ± 2.4	n.t.c	5.27 ± 0.17
17c	OH	H	OH	H	OH	70.3 ± 5.4	8.9 ± 1.8	5.87 ± 0.09
17d	H	OH	OH	H	OH	78.7 ± 3.8	4.9 ± 0.7	5.34 ± 0.23
17e	H	H	OH	OH	H	43.7 ± 3.6	n.t. c	2.70 ± 0.03
17f	N(CH3)2	H	OH	OH	H	49.5 ± 2.8	n.t. c	4.88 ±0.14
17g	OH	H	OH	OH	H	80.5 ± 3.8	4.6 ± 1.1	4.05 ± 0.23
17h	H	OH	OH	OH	H	82.8 ± 3.1	3.4 ± 0.5	4.55 ± 0.20
17i	H	H	H	OH	H	0	n.t. c	2.06 ± 0.04
17j	N(CH3)2	H	H	OH	H	0	n.t. c	2.41 ± 0.11
17k	OH	H	H	OH	H	12.3 ± 1.7	n.t. c	3.94 ± 0.20
17l	H	OH	H	OH	H	20.5 ± 2.4	n.t. c	4.45 ± 0.12
19a	OH	H	OH	H	OH	50.2 ± 3.5	21.7 ± 4.0	4.84 ± 0.31
19b	H	OH	OH	OH	H	58.8 ± 2.9	17.5 ± 2.1	4.09 ± 0.27
Resveratrol	—	—	—	—	—	61.2 ± 5.2	16.8 ± 3.8	5.33 ± 0.17
Curcumin	—	—	—	—	—	53.9 ± 1.9	13.7 ± 1.9	n.t. c
Ferulic acid	—	—	—	—	—	n.t. c	n.t. c	3.24 ± 0.21
(E)-1,3-Dimethoxy-5-(4-methoxystyryl)benzene	—	—	—	—	—	n.t. c	n.t. c	0.21 ± 0.02

^aThe thioflavin-T fluorescence method was used. The values are expressed as the mean ± SD of at least three independent measurements. All values were obtained at a compound concentration of 20 μM.

^bThe mean ± SD of three independent experiments. The data are expressed as μmol of Trolox equivalents/μmol of the test compound.

^cn.t. means not tested.

^dMean ± SD of at least three independent measurements.