Table 5.
Cylinder plate diffusion method (µg/mL) of synthesized derivatives.
| Cultures a | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| I | II | III | IV | V | VI | VII | |||||||||
| Time (h) | 24 | 48 | 24 | 48 | 24 | 48 | 24 | 48 | 24 | 48 | 24 | 48 | 24 | 48 | |
| Comp. | Conc.(µg/mL) | Zones of inhibition (mm) b,c,d | |||||||||||||
| 1 | 75 | 15 | 16 | 10 | 10 | 8 | 8 | 6 | 7 | 17 | 17 | 10 | 12 | 26 | 30 |
| 10b | 75 | / | / | / | / | / | / | / | / | / | / | / | / | / | / |
| 150 | / | / | / | / | / | / | / | / | / | / | / | / | / | / | |
| 13b | 75 | / | / | / | / | / | / | / | / | / | / | / | / | 22 | 23 |
| 150 | / | / | / | / | / | / | / | / | / | / | / | / | 30 | 37 | |
| 16b | 75 | 12 | 13 | 15 | 16 | / | / | 7 | 8 | 16 | 16 | 8 | 10 | 20 | 25 |
| Antibiotic | 10 | 26 | 24 | 20 | 19 | 24 | 25 | 52 | 53 | 24 | 23 | 21 | 21 | 26 | 23 |
a I S. aureus; II S. aureus (isolate); III M. lysodiecticus,;IV K. pneumonia; V B. subtilis, VI E. coli; VII C. albincans; b (/) means absence of an inhibition zone; the results are from experiments run in triplicate, SD=±3 mm; c ethanol solvent controls were negative; d Standards were tetracycline (10 mg/mL) and ketoconazole (10 mg/mL).