Figure 5.

Model of Trim5α–LC3B complex. The SPRY domains from Rhesus Trim5α (PDB code 4B3N) are positioned on the Trim5α Bbox coiled coil (PDB code 4TN3) by superposition of common residues. The structure of the RhT5α–LC3B complex (this work) was then superimposed on 4TN3 to position the LC3B molecules. This model positions the variable loops of the SPRY domain to recognize capsid, whereas the lipidation site at the C terminus of LC3B is available to be incorporated in the autophagosomal membrane.