Table 4.

Prediction of FDG PET metabolic changes

	Model 1*	Model 2†	Model 3‡	Model 4§
PCC
Mediterranean diet	0.010 (0.005) p=0.050	0.010 (0.005) p=0.048	0.010 (0.005) p=0.043
Physical activity	−0.000 (0.001)	−0.000 (0.001)	−0.000 (0.001)
Intellectual activity	0.005 (0.015)	0.004 (0.015)	0.004 (0.014)
Plasma homocysteine	0.004 (0.004)	0.004 (0.003)		0.004 (0.004)
Plasma cholesterol	0.000 (0.000)	0.000 (0.000)		−0.000 (0.000)
Body mass index	−0.001 (0.001)	−0.001 (0.001)		−0.001 (0.001)
QUICKI scores	0.165 (0.480)	0.184 (0.438)		0.049 (0.459)
Hypertension	0.001 (0.013)	0.003 (0.011)		−0.000 (0.011)
PCC FDG uptake at baseline	0.573 (0.194) p=0.006	0.587 (0.183) p=0.002	0.566 (0.184) p=0.003	0.515 (0.184) p=0.004
Sex	−0.003 (0.010)
APOE status	0.001 (0.008)
Age	0.000 (0.001)
Time to follow-up	−0.000 (0.000)
Constant	1.154 (0.080) p<0.001	1.154 (0.083) p<0.001	1.182 (0.007) p<0.001	1.173 (0.076) p<0.001
Frontal cortex
Mediterranean diet	−0.011 (0.007)	−0.012 (0.007) p=0.106	−0.012 (0.007) p=0.072
Physical activity	0.001 (0.001)	0.000 (0.001)	0.001 (0.001)
Intellectual activity	0.010 (0.020)	0.008 (0.019)	0.005 (0.019)
Plasma homocysteine	0.003 (0.005)	0.002 (0.005)		0.002 (0.005)
Plasma cholesterol	0.001 (0.000)	0.000 (0.000)		0.001 (0.000)
Body mass index	0.002 (0.002)	0.003 (0.002)		0.003 (0.002)
QUICKI scores	−0.116 (0.690)	−0.100 (0.669)		0.102 (0.668)
Hypertension	0.017 (0.018)	0.009 (0.015)		0.013 (0.015)
Frontal FDG uptake at baseline	0.202 (0.112) p=0.093	0.239 (0.107) p=0.040	0.196 (0.104) p=0.085	0.235 (0.101) p=0.036
Sex	0.007 (0.011)
APOE status	−0.006 (0.012)
Age	−0.001 (0.001) p=0.091
Time to follow-up	−0.000 (0.000)
Constant	1.209 (0.114) p<0.001	1.197 (0.111) p<0.001	1.174 (0.010) p<0.001	1.166 (0.110) p<0.001

See legend to table 2. Only significant and marginally significant p values are reported in the table.

APOE, apolipoprotein E; PCC, posterior cingulate cortex; QUICKI, Quantitative Insulin Sensitivity Check Index.