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. 2018 Sep 21;12(6):704–713. doi: 10.5009/gnl17515

Table 3.

The Results of a Cox Proportional Hazards Models for Gastric Variceal Rebleeding-Free Survival

Univariate analysis Multivariate analysis


HR (95% CI) p-value HR (95% CI) p-value
Age, yr 1.015 (0.996–1.034) 0.126 1.022 (0.999–1.045) 0.061
Female sex 0.535 (0.318–0.901) 0.019 0.537 (0.308–0.936) 0.028
Etiology of liver cirrhosis 0.092 - -
Concurrent HCC 2.252 (1.519–3.338) <0.001 2.102 (1.331–3.318) 0.001
Liver transplantation 0.234 (0.086–0.636) 0.004 0.234 (0.080–0.684) 0.008
GV type 0.933 - -
 GOV 2 0.953 (0.512–1.775) 0.880
 IGV 1 0.843 (0.430–1.652) 0.618
 IGV 2 1.117 (0.153–9.077) 0.876
Presence of active bleeding 1.669 (1.003–2.777) 0.049 1.383 (0.781–2.446) 0.266
Initial mean blood pressure 0.999 (0.986–1.011) 0.829
Initial hemoglobin 0.895 (0.822–0.974) 0.010
Time to intervention 1.000 (0.996–1.003) 0.790
Albumin, g/dL 0.567 (0.410–0.783) 0.001 0.570 (0.375–0.866) 0.009
Creatinine, mg/dL 1.058 (0.947–1.182) 0.319 - -
Total bilirubin, mg/dL 1.049 (1.022–1.078) <0.001 1.059 (1.021–1.099) 0.002
Prothrombin time, INR 1.812 (1.320–2.488) <0.001 1.440 (0.893–2.322) 0.135
Ascites 0.042 0.203
 Mild to moderate 1.651 (1.016–2.683) 0.043 1.408 (0.835–2.375) 0.199
 Severe 1.850 (0.951–3.601) 0.070 1.694 (0.817–3.510) 0.156
Portosystemic encephalopathy 0.933 - -
 Mild to moderate 1.147 (0.557–2.364) 0.710
 Severe 1.021 (0.413–2.523) 0.963
BRTO group 0.601 (0.352–1.025) 0.061 0.336 (0.178–0.633) 0.001

HR, hazard ratio; CI, confidential interval; HCC, hepatocellular carcinoma; GV, gastric varices; INR, international normalized ratio; BRTO, balloon-occluded retrograde transvenous obliteration.