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Combination indexes (CIx) versus affected fraction (fa) determined for combination of FK228 and oxaliplatin. Cells were treated with FK228/oxaliplatin for 72 h at fixed equitoxic ratios. CIx≤0.8, CIx≥1.2, and 0.8<CIx<1.2 indicate synergism, antagonism, and additivity, respectively (See methods for details).
