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. 2018 Nov 6;9(87):35762–35779. doi: 10.18632/oncotarget.26299

Figure 6. Nimbolide inhibits NF-κB activity.

Figure 6

(A) Motif screening of 25 kb upstream regions of 40 genes identified by COMPARE analysis revealed the significant presence of NF-κB-DNA binding motifs. (B) Various concentrations of nimbolide (0.001 μM. 0.01 μM. 0.1 μM and 1 μM) were used to treat SEAP-driven cells stimulated with TNF-α for 24 h and compared to the positive control triptolide (1 μM). The results show mean values ± SD of three independent experiments. (**p< 0.01, compared to DMSO control cells).