Table 1. Genes in P-glycoprotein-overexpressing CEM/ADR5000 cells those are consistent with PTEN activation after nimbolide treatment.
Gene symbol | Exper. Fold change | Gene symbol | Exper. Fold change |
---|---|---|---|
MXD4 | 2.325 | CXCR4 | −1.095 |
KLHL24 | 1.800 | FAS | −1.115 |
NDRG1 | 1.720 | CFD | −1.185 |
MEF2D | 1.290 | CCND1 | −1.185 |
AKR1C3 | 1.255 | MAPKAPK3 | −1.200 |
SAT1 | 1.215 | PA2G4 | −1.270 |
HSPA1A/HSPA1B | 1.215 | NOP2 | −1.320 |
TOM1 | 1.175 | SCD | −1.345 |
IFRD1 | 1.170 | VEGFB | −1.515 |
BTG1 | 1.090 | CDK4 | −1.590 |
KLF6 | 1.005 | ATP5MC1 | −1.680 |
ACACA | −1.010 | MRPL12 | −2.145 |
H2AFY | −1.015 | FASN | −2.355 |
SREBF1 | −1.025 | MYC | −4.260 |
SORD | −1.065 |
IPA program highlighted 29 genes from the dataset that have measurement directions in consistence with PTEN activation (p-value 7.98 × 10−13).